UNIVERSITY OF DAR ES SALAAM
COLLEGE OF NATURAL AND APPLIED SCIENCES (CONAS)

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SYLVESTER LYANTAGAYE

Teaching, research, public service, administration, College Of Natural And Applied Sciences
Education:

PhD. (Biochemistry)

Teaching:

Medical Biochemistry, Bioinformatics

Research:

Current Research

  1. Analysis of microbiome of push-pull intercropping system
  2. Evaluation of the impact of antibiotic therapies on vaginal microbiome and resistome of pregnant women
  3. Investigation on the diversity and rate of evolution in cassava chloroplast genome by using metagenomics tools
  4. Investigation of genetic diversity and bioactive metabolites of Spirulina species from selected ecosystems of Tanzania
  5. Investigation of the potential of Biopreservation in promoting costal fisheries livelihoods in Tanzania
  6. Green Nanotechnology: Search for Druggable Aptamer-delivered Anticancer Phytochemical.
  7. Mathematical modeling to measure HIV-1 viral load for limited resource areas.
  8. Genetic Screening for Hereditary Breast Cancer in Women and Their First Degree Relative in Tanzania (Tentative title)
  9. Determination of biochemical activities and genetic diversity of Rhisobia associated with selected Desmodium sp
  10. Postpartum Contraception in Tanzania: Studies of Acceptance, Complications and their Determinants

Projects:

Current Projects:

  1. Promoting Maternal Health by Exploiting Traditional Medicine in Tanzania: The Manufacturing and Commercializing Traditional Topical Contraceptives for Men And Women. Collaborators: Amelia Sylivery Buriyo, F. Mbago, Mona N Mwakalinga, Theodora Mwenegoha
  2. Exploring Recurrence of Dengue Epidemics in Tanzania: Climate Change and Industrialization Perspective. Collaborators: Clement Mweya, Christopher Hariri Mbotwa, Joyce Massaro, Simeon P. Mwanyonga, Liness Amos Ndelwa
  3. Fabrication of Medical Bandage Using Collagen Nanofibres Extracted from Bovine Horns and Hooves. Collaborators: Liberato Haule, Lutamyo Nambela

Publications:

  1. Oleg N Reva, Safronova A Larisa, Aneth D Mwakilili, Donatha Tibuhwa, Sylvester Lyantagaye, Wai Yin Chan, Stefanie Lutz, Christian H Ahrens, Joachim Vater, Rainer Borriss. 2020. "Complete genome sequence and epigenetic profile of Bacillus velezensisUCMB5140 used for plant and crop protection in comparison with other plant-associated Bacillus strains”. Applied Microbiology and Biotechnology. 104(17):7643-7656
  2. Reuben Maghembe, Donath Damian, Abdalah Makaranga, Stephen Samwel Nyandoro  Sylvester Leonard Lyantagaye, Souvik Kusari, and Rajni Hatti-Kaul (2020). Omics for Bioprospecting and Drug Discovery from Bacteria and Microalgae. Antibiotics 2020, 9, 229; doi:10.3390/antibiotics9050229 www.mdpi.com/journal/antibiotics
  3. Doreen M. Mgonja, Gladness E. Temu, Sylvester L. Lyantagaye, Abdalah Makaranga, Joseph C. Ndunguru and Nessie D. Luambano (2020). Plant parasitic nematodes occurrence and genetic diversity of banana cultivars grown in Tanzania.Plant Omics J.13 (01): 21-29. doi: 10.21475/POJ.13.01.20. p2085
  4. Doreen M. Mgonja, Gladness E. Temu, Joseph C. Ndunguru, Magreth F. Mziray, Sylvester L. Lyantagaye, Nessie D. Luambano (2020). Molecular approach to confirm traditional identification of Radopholus similis sampled in Tanzania. Journal of Nematology. 52: 1-8, DOI: https://doi.org/10.21307/jofnem-2020-020. License: (CC-BY-4.0)
  5. Fulgence Ntangere Mpenda, Christian Keambou Tiambo, Martina kyallo, John Juma, Roger Pelle, Sylvester Leonard Lyantagaye and Joram Buza. "Association of LEI0258 Marker Alleles and Susceptibility to Virulent Newcastle Disease Virus Infection in Kuroiler, Sasso, and Local Tanzanian Chicken Embryos," Journal of Pathogens, 2020: 1-8 Article ID 5187578, https://doi.org/10.1155/2020/5187578.
  6. Fulgence Ntangere Mpenda, Sylvester Leonard Lyantagaye and Joram Buza, (2020). Association of chicken Mx1 polymorphisms with susceptibility in chicken embryos challenged with virulent newcastle disease virus. Asian J. Anim. Sci., 14: 9-15.
  7. Fulgence Ntangere Mpenda, Sylvester Leonard Lyantagaye and Joram Buza, (2020). Immune response following Newcastle disease immunization and growth performance of kuroiler, broiler and local Tanzanian chickens. Int. J. Livest. Prod., 11(1): 1-7, January - March 2020, DOI: 10.5897/IJLP2019.0628
  8. Fulgence N. Mpenda, Christian T. Keambou, Martina Kyallo, Roger Pelle, Sylvester L. Lyantagaye, and Joram Buza (2019). Polymorphisms of the Chicken Mx Gene Promoter and Association with Chicken Embryos’ Susceptibility to Virulent Newcastle Disease Virus Challenge. BioMed Research International, vol. 2019, Article ID 1486072, 6 pages, 2019. https://doi.org/10.1155/2019/1486072.
  9. Doreen M Mgonja, Gladness E Temu, Magreth F Mziray, Beatrice E Kashando, Ambilikile E Mwenisongole, Minza M Masunga, Sylvester L Lyantagaye and Nessie D Luambano. (2019). Morphological and Molecular Identification of Pratylenchus goodeyi Associated with Banana in Tanzania. Tanzania Journal of Science 45(2): 265-278, 2019
  10. Oleg N. Reva1, Dirk Z. H. Swanevelder, Liberata Mwita, Aneth D. Mwakilili, Dillon Muzondiwa1, Monique Joubert1, Wia-Yin Chan, Stefanie Lutz, Christian H. Ahrens, Lylia V. Avdeeva, Maksim A. Kharkhota, Donatha Tibuhwa, Sylvester Lyantagaye, Joachim Vater, Rainer Borriss, Johan Meijer. (2019). Genetic, epigenetic and phenotypic diversity of four Bacillus velezensis strains used for plant protection or as probiotics. ACCEPTED FOR Publication in Frontiers in Microbiology.DOI: 10.3389/fmicb.2019.02610
  11. Anitha Philbert, Ph.D.; Sylvester Leonard Lyantagaye; Gamba Nkwengulila. (2019). Farmers’ pesticide usage practices in the malaria endemic region of north-western Tanzania: Implications to the control of malaria vectors. BMC Public Health (2019) 19:1456. https://doi.org/10.1186/s12889-019-7767-0
  12. Cyprian Beda Mpinda, Debra Meyer, Sylvester Leonard Lyantagaye. (2018). In vitro antimicrobial activity of extracts of selected plant species used in the management of HIV/AIDS in rural Bukoba, Kagera Tanzania. Submitted to the Tanzania Journal of Sciences. Tanz. J. Sci. Vol. 44 (1) 2018
  13. Philbert, A., Lyantagaye, S. L., Pradel, G., Ngwa, C. J. and Nkwengulila, G. (2017), Pyrethroids and DDT tolerance of Anopheles gambiae s.l. from Sengerema District, an area of intensive pesticide usage in north-western Tanzania. Trop Med Int Health, 22: 388–398. doi:10.1111/tmi.12850
  14. Liberata Mwita, Wai Yin Chan, Theresa Pretorius, Sylvester L. Lyantagaye, Svitlana V. Lapa, Lilia V. Avdeeva, Oleg N. Reva (2016). Gene expression regulation in the plant growth promoting Bacillus atrophaeus UCMB-5137 stimulated by maize root exudates. Gene, 590: 18–28.
  15. Nicola J. Mulder*, Ezekiel Adebiyi, Raouf Alami, Alia Benkahla, James Brandful, Seydou Doumbia, Dean Everett, Faisal M. Fadlelmola, Fatima Gaboun, Simani Gaseitsiwe, Hassan Ghazal, Scott Hazelhurst, Winston Hide, Azeddine Ibrahimi, Yasmina Jaufeerally Fakim, C. Victor Jongeneel, Fourie Joubert, Samar Kassim Jonathan Kayondo, Judit Kumuthini, Sylvester Lyantagaye, Julie Makani, Ahmed Mansour Alzohairy, Daniel Masiga, Ahmed Moussa, Oyekanmi Nash, Odile Ouwe Missi Oukem-Boyer, Ellis Owusu-Dabo, Sumir Panji, Hugh Patterton, Fouzia Radouani, Khalid Sadki, Fouad Seghrouchni, Özlem Tastan Bishop, Nicki Tiffin, Nzovu Ulenga, and the H3ABioNet Consortium#, as members of the H3Africa Consortium (2016). H3ABioNet, a Sustainable Pan-African Bioinformatics Network for Human Heredity and Health in Africa. Genome research,  2016 Feb; 26(2): 271–277.
  16. Shaaban J. Katani, Erick V. G. Komba, Alexanda Mzula, Sylvester L. Lyantagaye, Eva M. Sosovele and Hamisi M. Malebo (2014). Evidence of Carriage of Antimicrobial Resistant Salmonella species of Public Health and Veterinary Significance in the Intestines of House Crows (Corvus splendens) in Tanzania. International Journal of Tropical Diseases & Health 5(1): 64-70, 2015, Article no.IJTDH.2015.007.
  17. H3Africa Consortium, Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, Amodu O, Anabwani G, Andersen K, Arogundade F, Arulogun O, Asogun D, Bakare R, Balde N, Baniecki ML, Beiswanger C, Benkahla A, Bethke L, Boehnke M, Boima V, Brandful J, Brooks AI, Brosius FC, Brown C, Bucheton B, Burke DT, Burnett BG, Carrington-Lawrence S, Carstens N, Chisi J, Christoffels A, Cooper R, Cordell H, Crowther N, Croxton T, de Vries J, Derr L, Donkor P, Doumbia S, Duncanson A, Ekem I, El Sayed A, Engel ME, Enyaru JC, Everett D, Fadlelmola FM, Fakunle E, Fischbeck KH, Fischer A, Folarin O, Gamieldien J, Garry RF, Gaseitsiwe S, Gbadegesin R, Ghansah A, Giovanni M, Goesbeck P, Gomez-Olive FX, Grant DS, Grewal R, Guyer M, Hanchard NA, Happi CT, Hazelhurst S, Hennig BJ, Hertz- C, Fowler, Hide W, Hilderbrandt F, Hugo-Hamman C, Ibrahim ME, James R, Jaufeerally-Fakim Y, Jenkins C, Jentsch U, Jiang PP, Joloba M, Jongeneel V, Joubert F, Kader M, Kahn K, Kaleebu P, Kapiga SH, Kassim SK, Kasvosve I, Kayondo J, Keavney B, Kekitiinwa A, Khan SH, Kimmel P, King MC, Kleta R, Koffi M, Kopp J, Kretzler M, Kumuthini J, Kyobe S, Kyobutungi C, Lackland DT, Lacourciere KA, Landouré G, Lawlor R, Lehner T, Lesosky M, Levitt N, Littler K, Lombard Z, Loring JF, Lyantagaye S, Macleod A, Madden EB, Mahomva CR, Makani J, Mamven M, Marape M, Mardon G, Marshall P, Martin DP, Masiga D, Mason R, Mate-Kole M, Matovu E, Mayige M, Mayosi BM, Mbanya JC, McCurdy SA, McCarthy MI, McIlleron H, Mc'Ligeyo SO, Merle C, Mocumbi AO, Mondo C, Moran JV, Motala A, Moxey-Mims M, Mpoloka WS, Msefula CL, Mthiyane T, Mulder N, Mulugeta Gh, Mumba D, Musuku J, Nagdee M, Nash O, Ndiaye D, Nguyen AQ, Nicol M, Nkomazana O, Norris S, Nsangi B, Nyarko A, Nyirenda M, Obe E, Obiakor R, Oduro A, Ofori- SF, Ogah O, Ogendo S, Ohene-Frempong K, Ojo A, Olanrewaju T, Oli J, Osafo C, Ouwe Missi Oukem-Boyer O, Ovbiagele B, Owen A, Owolabi MO, Owolabi L, Owusu-Dabo E, Pare G, Parekh R, Patterton HG, Penno MB, Peterson J, Pieper R, Plange-Rhule J, Pollak M, Puzak J, Ramesar RS, Ramsay M, Rasooly R, Reddy S, Sabeti PC, Sagoe K, Salako T, Samassékou O, Sandhu MS, Sankoh O, Sarfo FS, Sarr M, Shaboodien G, Sidibe I, Simo G, Simuunza M, Smeeth L, Sobngwi E, Soodyall H, Sorgho H, Sow Bah O, Srinivasan S, Stein DJ, Susser ES, Swanepoel C, Tangwa G, Tareila A, Tastan Bishop O, Tayo B, Tiffin N, Tinto H, Tobin E, Tollman SM, Traoré M, Treadwell MJ, Troyer J, Tsimako-Johnstone M, Tukei V, Ulasi I, Ulenga N, van Rooyen B, Wachinou AP, Waddy SP, Wade A, Wayengera M, Whitworth J, Wideroff L, Winkler CA, Winnicki S, Wonkam A, Yewondwos M, sen T, Yozwiak N, Zar H. (2014). Research capacity. Enabling the genomic revolution in Africa  Science. 2014 Jun 20; 344 (6190): 1346-8. doi: 10.1126/science.1251546.
  18. R. Masalu, K.M.M. Hosea, M. Meyer, S.L. Lyantagaye, B. Ndimba (2014). Glucose Regulated Protein 78 (GRP 78) as a Cytoprotection against Apoptosis in Small Cell Lung Carcinoma. Current Trends in Biotechnology and Pharmacy, 8 (2): 185-191
  19. Anitha Philbert, Sylvester Leonard Lyantagaye, Gamba Nkwengulila (2014). A Review of Agricultural Pesticides Use and the Selection for Resistance to Insecticides in Malaria Vectors. Advances in Entomology, 2: 120-128
  20. Sylvester Leonard Lyantagaye (2014). Current status and future perspectives of Bioinformatics in Tanzania. Tanzania Journal of Sciences, 39: 1-11.
  21. Sylvester Leonard Lyantagaye (2014). Medicinal potential of Melodorum gracile and Mkilua fragrans extracts. Journal of Applied Pharmaceutical Sciences, 4(02): 008-011.
  22. Sylvester Leonard Lyantagaye (2013). Medicinal potential of Commiphorasponthulata, Hugoniacasteneifolia and Raphidiocystischrysocomaindigenous toTanzania. J. Chem. Bio. Phy. Sci. (B) 4(1): 287-292.
  23. Sylvester Leonard Lyantagaye (2013). Characterization of the biochemical pathway of apoptosis induced by three D-glucopyranoside derivatives from Tulbaghia violacea. Annual Research & Review in Biology. 4(6): 962-977.
  24. Sylvester Leonard Lyantagaye (2013). Two new pro-apoptotic glucopyranosides from Tulbaghia violacea. Journal of Medicinal Plants Research. 7(29): 2214-2220
  25. Tibuhwa, D.D, Lyantagaye, S.L and Mshandete, A.M. (2012) Effect of different post harvest treatments on nutritive and antioxidant activities of wild edible Coprinus cinereus (Schaeff.) S.Gray from Tanzania. International Journal of Research in Biological Sciences. 2(4): 150-156.
  26. Sylvester Leonard Lyantagaye (2013). Methyl-α-D-glucopyranoside from Tulbghia violacea extract induces apoptosis in vitro in cancer cells. Bangladesh J Pharmacol 8: 93-101
  27. Grace Langula, Sylvester Leonard Lyantagaye and Anthony Manoni Mshandete (2012). Production of iodized Saccharomyces cerevisiae edible yeast using brown seaweeds Sargassum sp media extract by submerged fermentation. International Journal of Advanced Biological Research (IJABR). 2(4):617-623.
  28. Sylvester L. Lyantagaye and Francis S. Magingo (2012). Stephanostema stenocarpum (Apocynaceae) extract is a potential remedy for bacterial infections in domestic animals. Journal of Medicinal Plants Research 6(35): 4915-4921.
  29. SL Lyantagaye(2011). Ethnopharmacological and phytochemical review of Allium species (sweet Garlic) and Tulbaghia species (wild Garlic) from Southern Africa. Tanzania Journal of Science. 37: 58-72
  30. Liberata Nyang’osoMwita, Sylvester Leonard Lyantagaye and Anthony ManoniMshandete(2011). Cultivation of Tanzanian Coprinus cinereus (sisal compost mushroom) on three non-composted sisal wastes substrates supplemented with chicken manure at various rates. Int. J. Biol. Chem. Sci.,  5 (3): 968-978.
  31. Rose MASALU, Ken M. HOSEA, Mervin MEYER, Sylvester LYANTAGAYE, Stonald Kanyanda (2010). Induction of early apoptosis and reactive oxygen species (ROS) production by Tanzanian basidiomycete (Cantharellus miomboensis). International Journal of Biological and Chemical Sciences, 4 (4):825-833.
  32. Theonest Ndyetabura, Sylvester Leonard Lyantagaye and Anthony ManoniMshandete (2010). Antimicrobial activities of ethyl acetate extracts from edible Tanzanian Coprinus cinereus (Schaeff) S. Gray s.lat. cultivated on grasses supplemented with cow dung manure. ARPN Journal of Agricultural and Biological Science; 5 (5) available on line September 2010.
  33. Liberata Nyang’osoMwita, Anthony ManoniMshandete and Sylvester Leonard Lyantagaye(2010). Improved antimicrobial activity of the Tanzanian edible mushroom Coprinus cinereus(Schaeff) S. Gray s.lat. by chicken manure supplemented solid sisal wastes substrates. Journal of Yeast and Fungal Research. 1(10): 202-207
  34. Liberata Nyang’osoMwita, Sylvester Leonard Lyantagaye and Anthony ManoniMshandete(2010). The effect of the interaction of varying chicken manure supplement levels with three different solid sisal wastes substratse on sporocarp cap length and diameters and dry weights of Coprinus cinereus(Schaeff) S. Gray s.lat. African Journal of Biotechnology. African Journal of Biotechnology. 10(7): 1172-1180.
  35. Frankline K. Keter, Stonard Kanyanda, Sylvester Lyantagaye, James Darkwa, D. Jasper G. Rees and Mervin Meyer. (2008). In vitro evaluation of dichloro-bis(pyrazole)palladium(II)  and dichloro-bis(pyrazole)platinum(II) complexes as anticancer agents. Cancer Chemotherapy and Pharmacology, 63 (1): 139-148.
  36. Lyantagaye SSL, Meyer M, McKenzie J and Rees DJG. (2005). Identification of -methyl D-glucose ether as the active compound from Tulbaghia violacea in the induction of apoptosis. FEBS Journal, 272: 37.
  37. Lyantagaye SSL, Rees DJG. (2003). Screening Tulbaghia violacea extracts for the presence of apoptotic compounds. South African Journal of Botany, 69: 256-257.
  38. Sylvester SL. Lyantagaye. Chapter-10: Apoptosis Regulation in Mosquito and its Importance to Malaria Infection. In: Raman Chandrasekar. Short Views on Insect Molecular Biology, Vol. (1), 175-190, (2009). International Book Mission Academic Publisher, India.