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THOMAS MARANDU

Lecturer, Mbeya College of Health and Allied Sciences
Education:

BSc(Hons), MSc, PhD

Teaching:

Immunology, Virology and Molecular Biology

Research:

2017 – 2019: Using Immunology, Virology and Molecular Biology techniques to understand how persistent herpesviruses affects host immunity (innate and adaptive immunity) – Prof. Charles Cook research lab-BIDMC, Department of Surgery

2010 – 2013: Immunology & virology: Working with mouse model of infection to monitor phenotypic and functional changes on T cells, B cells, neutrophils and NK cells associated with herpesviral infections. FACS – Prof. Luka  Cicin-Sain research lab – HZI, Immunosenescence and Chronic Infection group

2006 – 2008: Molecular Biology: gene expression analysis by using Real Time PCR - Dr. Patrick Duffy lab. Mother-offspring Malaria Study & Seattle Biomedical Research Institute

Publications:

  1. Marandu, T., Dombek, M., Cook, C.H. 2019. Impact of Cytomegalovirus Load on Host Response to Sepsis. Medical Microbiology and Immunolog https://link.springer.com/article/10.1007%2Fs00430-019-00603-y
  2. Dekhtiarenko, I., Ratts, R.B., Blatnik, R., Lee, L.N., Fischer, S., Borkner. L., Oduro, J., Marandu, T.F., Hoppe, Ruzsics, Z., Sonnemann, J.K., Mansour, M., Meyer, C., Lemmermann, N.A.W., Holtappels, R., Arens, R., Klenerman, P., Fruh, K., Reddehase, M.J., Riemer, A.B., Cicin-Sain, L. 2016. Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006072
  3. Marandu T.F., Oduro, J.D., Borkner, L., Dekhtiarenko,I., Uhrlaub, J., Drabig, A., Kroger, A., Nikolich-Zugich, J, Cicin-Sain, L. 2015. Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. Journal of Virology 89 (22): 11715 -11717 http://jvi.asm.org/content/early/2015/08/28/JVI.01989-15.abstract
  4. Oduro, J.D, Redeker, A., Lemmermann N, A., Ebermann, L., Marandu, T.F., Dekhtiarenko, I., Holzki,J.K., Busch, D., Arens, R., Čičin-Šain, L. 2015. Murine cytomegalovirus infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection. Journal of General Virology. doi: 10.1099/jgv.0.000339 http://jgv.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000339 
  5. Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, Cičin-Šain L, Dechanet-Merville J, Derhovanessian E, Ferrando-Martinez S, Franceschi C, Frasca D, Fulöp T, Furman D, Gkrania-Klotsas E, Goodrum F, Grubeck-Loebenstein B, Hurme M, Kern F, Lilleri D, López-Botet M, Maier AB, Marandu T, Marchant A, Matheï C, Moss P, Muntasell A, Remmerswaal EB, Riddell NE, Rothe K, Sauce D, Shin EC, Simanek AM, Smithey MJ, Söderberg-Nauclér C, Solana R, Thomas PG, van Lier R, Pawelec G, Nikolich-Zugich J. 2014. New advances in CMV and immunosenescence. Experimental Gerontology, 55:54-62 http://www.sciencedirect.com/science/article/pii/S0531556514000928
  6. Marandu T.F, Finsterbusch K, Kröger A, Čičin-Šain L. 2014. Mouse CMV infection delays antibody class switch upon an unrelated virus challenge. Experimental Gerontology, 54:101-8. http://www.sciencedirect.com/science/article/pii/S0531556514000291
  7. Cicin-Sain, L., Brien, J.D., Uhrlaub J.L., Drabig, A., Marandu, T.F, Nikolich-Zugich, J. 2012. Cytomegalovirus infection impairs immune responses and accentuates T-cell pool changes observed in mice with aging. Plos Pathogens 8 (8). http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002849